Trefoil factor 3 overexpression in prostatic carcinoma: Prognostic importance using tissue microarrays
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چکیده
منابع مشابه
Trefoil factor 3 overexpression in prostatic carcinoma: prognostic importance using tissue microarrays.
BACKGROUND Human intestinal trefoil factor 3 (TFF3) is a member of a family of polypeptides encoded by a cluster of genes on chromosome 21. Through gene expression profiling studies TFF3 mRNA has been found to be overexpressed in prostate cancer. METHODS We used immunochemistry on tissue microarrays and software tools, collectively referred to as TMAJ, for online assessment of staining to ana...
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Trefoil factor family members (TFF1− 3) are small secretory peptides on mucosal surfaces that regulate epithelial restitution and wound healing by promoting cell migration and antagonising apoptosis. They have, in common, a structural trefoil motif that is stabilised by three disulphide bonds. TFFs are often co-secreted with mucins by mucin-producing cells, helping to maintain epithelial integr...
متن کاملTrefoil factor 3 mediation of oncogenicity and chemoresistance in hepatocellular carcinoma is AKT-BCL-2 dependent
The efficacious treatment of hepatocellular carcinoma (HCC) remains a challenge, partially being attributed to intrinsic chemoresistance. Previous reports have observed increased TFF3 expression in HCC. Herein, we investigated the functional role of TFF3 in progression of HCC, and in both intrinsic and acquired chemoresistance. TFF3 expression was observed to be upregulated in HCC and associate...
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Background: Numerous studies confirmed that significant decrease in tissue decorin (DCN) expression is associated to tumor progression and metastasis in certain types of cancer including prostate cancer (PC). However, the potential prognostic value of tissue DCN in PC has not yet been investigated. Methods: A total number of 40 PC and 42 patients with benign prostatic hyperplasia (BPH) were inv...
متن کاملTrefoil factor 3 immunohistochemical characterization of follicular thyroid lesions from tissue microarray.
OBJECTIVES To characterize trefoil factor 3 (TFF3) expression in normal thyroid tissue samples compared with that in follicular adenoma, follicular carcinoma, and follicular variant of papillary thyroid carcinoma using immunohistochemistry on tissue microarrays. DESIGN Immunohistochemical analysis of 83 normal thyroid tissue and of 83 follicular neoplasms (26 follicular adenomas, 25 follicula...
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ژورنال
عنوان ژورنال: The Prostate
سال: 2004
ISSN: 0270-4137,1097-0045
DOI: 10.1002/pros.20095